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23 Mart 2025

Dr. Over Black Cohosh’un formülasyonunda kaynak olarak yararlanılan bilimsel yayınlar:

  • Franco OH, Chowdhury R, Troup J, et al. Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis. 2016;315(23):2554–2563. doi:10.1001/jama.2016.8012

 

  • Kenda M, Glavač NK, Nagy M, Sollner Dolenc M, On Behalf Of The Oemonom. Herbal Products Used in Menopause and for Gynecological Disorders. Molecules. 2021 Dec 8;26(24):7421. doi: 10.3390/molecules26247421. PMID: 34946512; PMCID: PMC8708702.

 

  • Mehrpooya M, Rabiee S, Larki-Harchegani A, Fallahian AM, Moradi A, Ataei S, Javad MT. A comparative study on the effect of “black cohosh” and “evening primrose oil” on menopausal hot flashes. J Educ Health Promot. 2018 Mar 1;7:36. doi: 10.4103/jehp.jehp_81_17. PMID: 29619387; PMCID: PMC5868221.

 

  • Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women’s Health. Pharmacol Rev. 2016 Oct;68(4):1026-1073. doi: 10.1124/pr.115.010843. PMID: 27677719; PMCID: PMC5050441.

 

  • Najaf Najafi M, Ghazanfarpour M. Effect of phytoestrogens on sexual function in menopausal women: a systematic review and meta-analysis. Climacteric. 2018 Oct;21(5):437-445. doi: 10.1080/13697137.2018.1472566. Epub 2018 Aug 29. PMID: 30156931.

 

  • Lupsa BC, Insogna K. Bone Health and Osteoporosis. Endocrinol Metab Clin North Am. 2015 Sep;44(3):517-30. doi: 10.1016/j.ecl.2015.05.002. PMID: 26316240.

 

  • Remport J, Blázovics A. Fitoösztrogének a menopauza terápiájában [Phytoestrogens in the treatment of menopause]. Orv Hetil. 2017 Aug;158(32):1243-1251. Hungarian. doi: 10.1556/650.2017.30805. PMID: 28780881.

 

  • Taebi M, Abdolahian S, Ozgoli G, Ebadi A, Kariman N. Strategies to improve menopausal quality of life: A systematic review. J Educ Health Promot. 2018 Jul 6;7:93. doi: 10.4103/jehp.jehp_137_17. PMID: 30079364; PMCID: PMC6052783.

 

  • Ghazanfarpour M, Sadeghi R, Latifnejad Roudsari R, Mirzaii Najmabadi K, Mousavi Bazaz M, Abdolahian S, Khadivzadeh T. Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis. Avicenna J Phytomed. 2015 Nov-Dec;5(6):498-511. PMID: 26693407; PMCID: PMC4678495.

 

  • Markus Lipovac, Peter Chedraui, Christine Gruenhut, Anca Gocan, Christine Kurz, Benedikt Neuber, Martin Imhof, “Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women”, Obstetrics and Gynecology International, vol. 2011, Article ID 949302, 6 pages, 2011. doi: 10.1155/2011/949302

 

  • Myers SP, Vigar V. Effects of a standardised extract of Trifolium pratense (Promensil) at a dosage of 80mg in the treatment of menopausal hot flushes: A systematic review and meta-analysis. Phytomedicine. 2017 Jan 15;24:141-147. doi: 10.1016/j.phymed.2016.12.003. Epub 2016 Dec 12. PMID: 28160855.

 

  • Cagnacci, Angelo. (2021). Phytotherapy for menopausal symptoms: recommendations of the Italian Menopause Society (SIM) and the Italian Society of Gynaecology for the Third Age (SIGiTE). Italian Journal of Gynaecology and Obstetrics. 33. 214. 10.36129/jog.33.04.01.

 

  • Ismail R, Taylor-Swanson L, Thomas A, Schnall JG, Cray L, Mitchell ES, Woods NF. Effects of herbal preparations on symptom clusters during the menopausal transition. Climacteric. 2015 Feb;18(1):11-28. doi: 10.3109/13697137.2014.900746. Epub 2014 Jul 4. PMID: 24605800.

 

  • Lerchbaum E. Vitamin D and menopause–a narrative review. Maturitas. 2014 Sep;79(1):3-7. doi: 10.1016/j.maturitas.2014.06.003. Epub 2014 Jun 13. PMID: 24993517.

 

  • Ferraris, C., Ballestra, B., Listorti, C. et al.Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Res Treat 180, 157–165 (2020). doi: 10.1007/s10549-020-05534-4

 

  • Antonescu A-I, Miere F, Fritea L, Ganea M, Zdrinca M, Dobjanschi L, Antonescu A, Vicas SI, Bodog F, Sindhu RK, Cavalu S. Perspectives on the Combined Effects of Ocimum basilicumand Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects. Plants. 2021; 10(7):1390. doi:10.3390/plants10071390

 

  • Moore TR, Franks RB, Fox C. Review of Efficacy of Complementary and Alternative Medicine Treatments for Menopausal Symptoms. J Midwifery Womens Health. 2017 May;62(3):286-297. doi: 10.1111/jmwh.12628. Epub 2017 May 31. PMID: 28561959.

 

  • Ghazanfarpour, R. Sadeghi, R. Latifnejad Roudsari, I. Khorsand, T. Khadivzadeh & B. Muoio(2016) Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis, Journal of Obstetrics and Gynaecology, 36:3, 301-311, DOI: 10.3109/01443615.2015.1049249

 

  • Chen MN, Lin CC, Liu CF. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric. 2015 Apr;18(2):260-9. doi: 10.3109/13697137.2014.966241. Epub 2014 Dec 1. PMID: 25263312; PMCID: PMC4389700.

 

  • -M. Beer, A. Neff, “Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa‘s Efficacy and Safety for Climacteric Complaints”, Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 860602, 21 pages, 2013. doi/10.1155/2013/860602

 

  • Henneicke-von Zepelin HH. 60 years of Cimicifuga racemosa medicinal products : Clinical research milestones, current study findings and current development. Wien Med Wochenschr. 2017 May;167(7-8):147-159. doi: 10.1007/s10354-016-0537-z. Epub 2017 Feb 2. PMID: 28155126; PMCID: PMC5409920.

 

  • Lee HW, Choi TY, Lee MS, Lee JA, Jun JH, Choi J, Ang L, Lee CH, Lee JM, Park KS, Kim DC, Jang SR, Yoo JE, Kim DI, Cho SH, Yang SJ, Lee IS, Ahn IS, Lee DN, Choi CM, Song MH, Kim E. Prescription patterns of herbal medicine for menopausal disorders in major Korean medicine hospitals: a multicenter retrospective study. Integr Med Res. 2021 Sep;10(3):100706. doi: 10.1016/j.imr.2020.100706. Epub 2020 Dec 4. PMID: 33665094; PMCID: PMC7903342.

 

  • Li Y, Ma H, Lu Y, Tan BJ, Xu L, Lawal TO, Mahady GB, Liu D. Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis. Biomed Res Int. 2016;2016:2574637. doi: 10.1155/2016/2574637. Epub 2016 Feb 14. PMID: 26981526; PMCID: PMC4769746.

 

  • Hajirahimkhan A, Dietz BM, Bolton JL. Botanical modulation of menopausal symptoms: mechanisms of action? Planta Med. 2013 May;79(7):538-53. doi: 10.1055/s-0032-1328187. Epub 2013 Feb 13. PMID: 23408273; PMCID: PMC3800090.

 

  • Radzinsky VE, Uspenskaya Y, Shulman LP, Kuznetsova IV. Succinate-Based Dietary Supplement for Menopausal Symptoms: A Pooled Analysis of Two Identical Randomized, Double-Blind, Placebo-Controlled Clinical Trials. Obstet Gynecol Int. 2019 Oct 31;2019:1572196. doi: 10.1155/2019/1572196. PMID: 31781230; PMCID: PMC6875258.

 

  • Jurgens T, Chan B, Caron C, Whelan AM. A comparative analysis of recommendations provided by clinical practice guideline for use of natural health products in the treatment of menopause-related vasomotor symptoms. Complement Ther Med. 2020 Mar;49:102285. doi: 10.1016/j.ctim.2019.102285. Epub 2019 Dec 28. PMID: 32147040.

 

  • Castelo-Branco C, Gambacciani M, Cano A, Minkin MJ, Rachoń D, Ruan X, Beer AM, Schnitker J, Henneicke-von Zepelin HH, Pickartz S. Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence. Climacteric. 2021 Apr;24(2):109-119. doi: 10.1080/13697137.2020.1820477. Epub 2020 Oct 6. PMID: 33021111.

 

  • Thompson EA. Alternative and complementary therapies for the menopause: a homeopathic approach. Maturitas. 2010 Aug;66(4):350-4. doi: 10.1016/j.maturitas.2010.02.003. Epub 2010 Mar 6. PMID: 20207087.

 

  • Mahady GB. Is black cohosh estrogenic? Nutr Rev. 2003 May;61(5 Pt 1):183-6. doi: 10.1301/nr.2003.may.183-186. PMID: 12822708.

 

  • Wuttke W, Seidlová-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas. 2003 Mar 14;44 Suppl 1:S67-77. doi: 10.1016/s0378-5122(02)00350-x. PMID: 12609561.

 

  • Jiang, B., Reynertson, K. A., Keller, A. C., Einbond, L. S., Bemis, D. L., Weinstein, I. B., Kronenberg, F., & Kennelly, E. J. (2008). Extraction Methods Play a Critical Role in Chemical Profile and Biological Activities of Black Cohosh. Natural Product Communications. Vol. 3 (9), pages 1519-1532 doi:10.1177/1934578X0800300925

 

  • Osmers R, Friede M, Liske E, Schnitker J, Freudenstein J, Henneicke-von Zepelin HH. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol. 2005 May;105(5 Pt 1):1074-83. doi: 10.1097/01.AOG.0000158865.98070.89. Erratum in: Obstet Gynecol. 2005 Sep;106(3):644. PMID: 15863547.

 

  • Clement YN, Onakpoya I, Hung SK, Ernst E. Effects of herbal and dietary supplements on cognition in menopause: a systematic review. Maturitas. 2011 Mar;68(3):256-63. doi: 10.1016/j.maturitas.2010.12.005. Epub 2011 Jan 14. PMID: 21237589.

 

  • Gafner, Stefan. (2016). Black Cohosh Botanical Adulterants Bulletin.

 

  • Dennehy C, Tsourounis C. A review of select vitamins and minerals used by postmenopausal women. Maturitas. 2010 Aug;66(4):370-80. doi: 10.1016/j.maturitas.2010.06.003. Epub 2010 Jun 26. PMID: 20580500.

 

  • Drewe J, Bucher KA, Zahner C. A systematic review of non-hormonal treatments of vasomotor symptoms in climacteric and cancer patients. Springerplus. 2015 Feb 10;4:65. doi: 10.1186/s40064-015-0808-y. PMID: 25713759; PMCID: PMC4331402.

 

  • Zhu X, Liew Y, Liu ZL. Chinese herbal medicine for menopausal symptoms. Cochrane Database Syst Rev. 2016 Mar 15;3:CD009023. doi: 10.1002/14651858.CD009023.pub2. PMID: 26976671; PMCID: PMC4951187.

 

  • Lin WL, Lin PY, Hung YC, Hsueh TP. Benefits of Herbal Medicine on Bone Mineral Density in Osteoporosis: A Meta-Analysis of Randomized Controlled Trials. Am J Chin Med. 2020;48(8):1749-1768. doi: 10.1142/S0192415X20500871. Epub 2020 Dec 10. PMID: 33308099.

 

  • Low Dog T. Menopause: a review of botanical dietary supplements. Am J Med. 2005 Dec 19;118 Suppl 12B:98-108. doi: 10.1016/j.amjmed.2005.09.044. PMID: 16414334.

 

  • Borrelli F, Ernst E. Alternative and complementary therapies for the menopause. Maturitas. 2010 Aug;66(4):333-43. doi: 10.1016/j.maturitas.2010.05.010. Epub 2010 Jun 30. PMID: 20580501.

 

  • Pitkin J. Alternative and complementary therapies for the menopause. Menopause Int. 2012 Mar;18(1):20-7. doi: 10.1258/mi.2012.012001. PMID: 22393177.

 

  • Hocké C, Diaz M, Bernard V, Frantz S, Lambert M, Mathieu C, Grellety-Cherbero M. Syndrome génito-urinaire de la ménopause (SGUM). RPC les femmes ménopausées du CNGOF et du GEMVi [Genitourinary menopause syndrome. Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines]. Gynecol Obstet Fertil Senol. 2021 May;49(5):394-413. French. doi: 10.1016/j.gofs.2021.03.025. Epub 2021 Mar 20. PMID: 33757926.

 

  • Antonescu Mintas AI, Miere Groza F, Fritea L, Ganea M, Zdrinca M, Dobjanschi L, Antonescu A, Vicas SI, Bodog F, Sindhu RK, Cavalu S. Perspectives on the Combined Effects of Ocimum basilicumand Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects. Plants (Basel). 2021 Jul 7;10(7):1390. doi: 10.3390/plants10071390. PMID: 34371593; PMCID: PMC8309466.

 

  • Ziaei S, Kazemnejad A, Zareai M. The effect of vitamin E on hot flashes in menopausal women. Gynecol Obstet Invest. 2007;64(4):204-7. doi: 10.1159/000106491. Epub 2007 Jul 30. PMID: 17664882.

 

  • Cutson TM, Meuleman E. Managing menopause. Am Fam Physician. 2000 Mar 1;61(5):1391-400, 1405-6. PMID: 10735345.

 

  • Davis SR, Baber RJ. Treating menopause – MHT and beyond. Nat Rev Endocrinol. 2022 Aug;18(8):490-502. doi: 10.1038/s41574-022-00685-4. Epub 2022 May 27. PMID: 35624141.

 

  • Vaccaro CM, Capozzi A, Ettore G, Bernorio R, Cagnacci A, Gambacciani M, Coletta V, Maffei S, Nappi RE, Scambia G, Viora E, Lello S. What women think about menopause: An Italian survey. Maturitas. 2021 May;147:47-52. doi: 10.1016/j.maturitas.2021.03.007. Epub 2021 Mar 15. PMID: 33744064.

 

  • Cagnacci, Angelo. (2021). Phytotherapy for menopausal symptoms: recommendations of the Italian Menopause Society (SIM) and the Italian Society of Gynaecology for the Third Age (SIGiTE). Italian Journal of Gynaecology and Obstetrics. 33. 214. 10.36129/jog.33.04.01.

 

  • Hidalgo LA, Chedraui PA, Morocho N, Ross S, San Miguel G. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol. 2005 Nov;21(5):257-64. doi: 10.1080/09513590500361192. PMID: 16373244.

 

  • Bachmann G. Sexual pain in the menopausal patient: individualizing treatment still best. Menopause. 2019 Aug;26(8):809-810. doi: 10.1097/GME.0000000000001361. PMID: 31090555.

 

  • Nonhormonal management of menopause-associated vasomotor symptoms: 2015 position statement of The North American Menopause Society. Menopause. 2015 Nov;22(11):1155-72; quiz 1173-4. doi: 10.1097/GME.0000000000000546. PMID: 26382310.

 

  • Miroddi M, Calapai G, Navarra M, Minciullo PL, Gangemi S. Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. J Ethnopharmacol. 2013 Dec 12;150(3):791-804. doi: 10.1016/j.jep.2013.09.047. Epub 2013 Oct 17. PMID: 24140586.

 

  • Huntley A. Drug-herb interactions with herbal medicines for menopause. J Br Menopause Soc. 2004 Dec;10(4):162-5. doi: 10.1258/1362180042721067. PMID: 15667753.

 

  • Depypere HT, Comhaire FH. Herbal preparations for the menopause: beyond isoflavones and black cohosh. Maturitas. 2014 Feb;77(2):191-4. doi: 10.1016/j.maturitas.2013.11.001. Epub 2013 Nov 19. PMID: 24314619.

 

  • Comhaire FH, Depypere HT. Hormones, herbal preparations and nutriceuticals for a better life after the menopause: part I. Climacteric. 2015 Jun;18(3):358-63. doi: 10.3109/13697137.2014.985645. Epub 2015 Feb 10. PMID: 25668235.

 

  • Comhaire FH, Depypere HT. Hormones, herbal preparations and nutriceuticals for a better life after the menopause: part II. Climacteric. 2015 Jun;18(3):364-71. doi: 10.3109/13697137.2014.985646. Epub 2015 Feb 10. PMID: 25668332.

 

  • Capozzi A, Scambia G, Lello S. Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletal health. Maturitas. 2020 Oct;140:55-63. doi: 10.1016/j.maturitas.2020.05.020. Epub 2020 May 30. PMID: 32972636.

 

  • Kargozar R, Azizi H, Salari R. A review of effective herbal medicines in controlling menopausal symptoms. Electron Physician. 2017 Nov 25;9(11):5826-5833. doi: 10.19082/5826. PMID: 29403626; PMCID: PMC5783135.

 

  • Wójcik A, Bartnicka E, Namieciński P, Rotsztejn H. Influence of the complex of retinol-vitamin C on skin surface lipids. J Cosmet Dermatol. 2015 Jun;14(2):92-9. doi: 10.1111/jocd.12140. Epub 2015 Mar 24. PMID: 25810364.

 

  • Kass-Annese B. Alternative therapies for menopause. Clin Obstet Gynecol. 2000 Mar;43(1):162-83. doi: 10.1097/00003081-200003000-00018. PMID: 10694998.

 

  • Kamronrithisorn T, Manonai J, Vallibhakara SA, Sophonsritsuk A, Vallibhakara O. Effect of Vitamin D Supplement on Vulvovaginal Atrophy of the Menopause. Nutrients. 2020 Sep 21;12(9):2876. doi: 10.3390/nu12092876. PMID: 32967068; PMCID: PMC7551270.

 

  • Słupski W, Jawień P, Nowak B. Botanicals in Postmenopausal Osteoporosis. Nutrients. 2021 May 11;13(5):1609. doi: 10.3390/nu13051609. PMID: 34064936; PMCID: PMC8151026.

 

  • Kim M, Lim HS, Lee HH, Kim TH. Role Identification of Passiflora Incarnata Linnaeus: A Mini Review. J Menopausal Med. 2017 Dec;23(3):156-159. doi: 10.6118/jmm.2017.23.3.156. Epub 2017 Dec 29. PMID: 29354614; PMCID: PMC5770524.

 

  • Dailey RK, Neale AV, Northrup J, West P, Schwartz KL. Herbal product use and menopause symptom relief in primary care patients: a MetroNet study. J Womens Health (Larchmt). 2003 Sep;12(7):633-41. doi: 10.1089/154099903322404285. PMID: 14583104.

 

  • Ko SH, Kim HS. Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women. Nutrients. 2020 Jan 13;12(1):202. doi: 10.3390/nu12010202. PMID: 31941004; PMCID: PMC7019719.

 

  • López-Baena MT, Pérez-Roncero GR, Pérez-López FR, Mezones-Holguín E, Chedraui P. Vitamin D, menopause, and aging: quo vadis? Climacteric. 2020 Apr;23(2):123-129. doi: 10.1080/13697137.2019.1682543. Epub 2019 Nov 18. PMID: 31736391.lups

 

  • De Franciscis P, Colacurci N, Riemma G, Conte A, Pittana E, Guida M, Schiattarella A. A Nutraceutical Approach to Menopausal Complaints. Medicina (Kaunas). 2019 Aug 28;55(9):544. doi: 10.3390/medicina55090544. PMID: 31466381; PMCID: PMC6780855.

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