Dr. Over markalı Black Cohosh ( Karayılan Otu, Soya, Kızıl Yonca, Passiflora, Folik Asit, Vitamin E, C, D3, K, B6, B12
İçeren Gıda Takviyemizin formülasyonunda faydalanılan bilimsel çalışmalar:
1- Franco OH, Chowdhury R, Troup J, et al. Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis. JAMA. 2016;315(23):2554–2563. doi:10.1001/jama.2016.8012
Menopoz semptomları hakkında
2- Kenda M, Glavač NK, Nagy M, Sollner Dolenc M, On Behalf Of The Oemonom. Herbal Products Used in Menopause and for Gynecological Disorders. Molecules. 2021 Dec 8;26(24):7421. doi: 10.3390/molecules26247421. PMID: 34946512; PMCID: PMC8708702.
3- Mehrpooya M, Rabiee S, Larki-Harchegani A, Fallahian AM, Moradi A, Ataei S, Javad MT. A comparative study on the effect of "black cohosh" and "evening primrose oil" on menopausal hot flashes. J Educ Health Promot. 2018 Mar 1;7:36. doi: 10.4103/jehp.jehp_81_17. PMID: 29619387; PMCID: PMC5868221.
Menopoz ve sıcak - ateş basması hakkında
4- Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women's Health. Pharmacol Rev. 2016 Oct;68(4):1026-1073. doi: 10.1124/pr.115.010843. PMID: 27677719; PMCID: PMC5050441.
5- Najaf Najafi M, Ghazanfarpour M. Effect of phytoestrogens on sexual function in menopausal women: a systematic review and meta-analysis. Climacteric. 2018 Oct;21(5):437-445. doi: 10.1080/13697137.2018.1472566. Epub 2018 Aug 29. PMID: 30156931.
6- Lupsa BC, Insogna K. Bone Health and Osteoporosis. Endocrinol Metab Clin North Am. 2015 Sep;44(3):517-30. doi: 10.1016/j.ecl.2015.05.002. PMID: 26316240.
7- Remport J, Blázovics A. Fitoösztrogének a menopauza terápiájában [Phytoestrogens in the treatment of menopause]. Orv Hetil. 2017 Aug;158(32):1243-1251. Hungarian. doi: 10.1556/650.2017.30805. PMID: 28780881.
8- Taebi M, Abdolahian S, Ozgoli G, Ebadi A, Kariman N. Strategies to improve menopausal quality of life: A systematic review. J Educ Health Promot. 2018 Jul 6;7:93. doi: 10.4103/jehp.jehp_137_17. PMID: 30079364; PMCID: PMC6052783.
9- Ghazanfarpour M, Sadeghi R, Latifnejad Roudsari R, Mirzaii Najmabadi K, Mousavi Bazaz M, Abdolahian S, Khadivzadeh T. Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis. Avicenna J Phytomed. 2015 Nov-Dec;5(6):498-511. PMID: 26693407; PMCID: PMC4678495.
10- Markus Lipovac, Peter Chedraui, Christine Gruenhut, Anca Gocan, Christine Kurz, Benedikt Neuber, Martin Imhof, "Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women", Obstetrics and Gynecology International, vol. 2011, Article ID 949302, 6 pages, 2011. doi: 10.1155/2011/949302
11- Myers SP, Vigar V. Effects of a standardised extract of Trifolium pratense (Promensil) at a dosage of 80mg in the treatment of menopausal hot flushes: A systematic review and meta-analysis. Phytomedicine. 2017 Jan 15;24:141-147. doi: 10.1016/j.phymed.2016.12.003. Epub 2016 Dec 12. PMID: 28160855.
12- Cagnacci, Angelo. (2021). Phytotherapy for menopausal symptoms: recommendations of the Italian Menopause Society (SIM) and the Italian Society of Gynaecology for the Third Age (SIGiTE). Italian Journal of Gynaecology and Obstetrics. 33. 214. 10.36129/jog.33.04.01.
13- Ismail R, Taylor-Swanson L, Thomas A, Schnall JG, Cray L, Mitchell ES, Woods NF. Effects of herbal preparations on symptom clusters during the menopausal transition. Climacteric. 2015 Feb;18(1):11-28. doi: 10.3109/13697137.2014.900746. Epub 2014 Jul 4. PMID: 24605800.
14- Lerchbaum E. Vitamin D and menopause--a narrative review. Maturitas. 2014 Sep;79(1):3-7. doi: 10.1016/j.maturitas.2014.06.003. Epub 2014 Jun 13. PMID: 24993517.
15- Ferraris, C., Ballestra, B., Listorti, C. et al. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Res Treat 180, 157–165 (2020). doi: 10.1007/s10549-020-05534-4
16- Antonescu A-I, Miere F, Fritea L, Ganea M, Zdrinca M, Dobjanschi L, Antonescu A, Vicas SI, Bodog F, Sindhu RK, Cavalu S. Perspectives on the Combined Effects of Ocimum basilicum and Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects. Plants. 2021; 10(7):1390. doi:10.3390/plants10071390
17- Moore TR, Franks RB, Fox C. Review of Efficacy of Complementary and Alternative Medicine Treatments for Menopausal Symptoms. J Midwifery Womens Health. 2017 May;62(3):286-297. doi: 10.1111/jmwh.12628. Epub 2017 May 31. PMID: 28561959.
18- M. Ghazanfarpour, R. Sadeghi, R. Latifnejad Roudsari, I. Khorsand, T. Khadivzadeh & B. Muoio (2016) Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis, Journal of Obstetrics and Gynaecology, 36:3, 301-311, DOI: 10.3109/01443615.2015.1049249
19- Chen MN, Lin CC, Liu CF. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric. 2015 Apr;18(2):260-9. doi: 10.3109/13697137.2014.966241. Epub 2014 Dec 1. PMID: 25263312; PMCID: PMC4389700.
20- A.-M. Beer, A. Neff, "Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints", Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 860602, 21 pages, 2013. doi/10.1155/2013/860602
21- Henneicke-von Zepelin HH. 60 years of Cimicifuga racemosa medicinal products : Clinical research milestones, current study findings and current development. Wien Med Wochenschr. 2017 May;167(7-8):147-159. doi: 10.1007/s10354-016-0537-z. Epub 2017 Feb 2. PMID: 28155126; PMCID: PMC5409920.
22- Lee HW, Choi TY, Lee MS, Lee JA, Jun JH, Choi J, Ang L, Lee CH, Lee JM, Park KS, Kim DC, Jang SR, Yoo JE, Kim DI, Cho SH, Yang SJ, Lee IS, Ahn IS, Lee DN, Choi CM, Song MH, Kim E. Prescription patterns of herbal medicine for menopausal disorders in major Korean medicine hospitals: a multicenter retrospective study. Integr Med Res. 2021 Sep;10(3):100706. doi: 10.1016/j.imr.2020.100706. Epub 2020 Dec 4. PMID: 33665094; PMCID: PMC7903342.
23- Li Y, Ma H, Lu Y, Tan BJ, Xu L, Lawal TO, Mahady GB, Liu D. Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis. Biomed Res Int. 2016;2016:2574637. doi: 10.1155/2016/2574637. Epub 2016 Feb 14. PMID: 26981526; PMCID: PMC4769746.
24- Hajirahimkhan A, Dietz BM, Bolton JL. Botanical modulation of menopausal symptoms: mechanisms of action? Planta Med. 2013 May;79(7):538-53. doi: 10.1055/s-0032-1328187. Epub 2013 Feb 13. PMID: 23408273; PMCID: PMC3800090.
25- Radzinsky VE, Uspenskaya Y, Shulman LP, Kuznetsova IV. Succinate-Based Dietary Supplement for Menopausal Symptoms: A Pooled Analysis of Two Identical Randomized, Double-Blind, Placebo-Controlled Clinical Trials. Obstet Gynecol Int. 2019 Oct 31;2019:1572196. doi: 10.1155/2019/1572196. PMID: 31781230; PMCID: PMC6875258.
26- Jurgens T, Chan B, Caron C, Whelan AM. A comparative analysis of recommendations provided by clinical practice guideline for use of natural health products in the treatment of menopause-related vasomotor symptoms. Complement Ther Med. 2020 Mar;49:102285. doi: 10.1016/j.ctim.2019.102285. Epub 2019 Dec 28. PMID: 32147040.
27- Castelo-Branco C, Gambacciani M, Cano A, Minkin MJ, Rachoń D, Ruan X, Beer AM, Schnitker J, Henneicke-von Zepelin HH, Pickartz S. Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence. Climacteric. 2021 Apr;24(2):109-119. doi: 10.1080/13697137.2020.1820477. Epub 2020 Oct 6. PMID: 33021111.
28- Thompson EA. Alternative and complementary therapies for the menopause: a homeopathic approach. Maturitas. 2010 Aug;66(4):350-4. doi: 10.1016/j.maturitas.2010.02.003. Epub 2010 Mar 6. PMID: 20207087.
29- Mahady GB. Is black cohosh estrogenic? Nutr Rev. 2003 May;61(5 Pt 1):183-6. doi: 10.1301/nr.2003.may.183-186. PMID: 12822708.
30- Wuttke W, Seidlová-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas. 2003 Mar 14;44 Suppl 1:S67-77. doi: 10.1016/s0378-5122(02)00350-x. PMID: 12609561.
31- Jiang, B., Reynertson, K. A., Keller, A. C., Einbond, L. S., Bemis, D. L., Weinstein, I. B., Kronenberg, F., & Kennelly, E. J. (2008). Extraction Methods Play a Critical Role in Chemical Profile and Biological Activities of Black Cohosh. Natural Product Communications. Vol. 3 (9), pages 1519-1532 doi:10.1177/1934578X0800300925
32- Osmers R, Friede M, Liske E, Schnitker J, Freudenstein J, Henneicke-von Zepelin HH. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol. 2005 May;105(5 Pt 1):1074-83. doi: 10.1097/01.AOG.0000158865.98070.89. Erratum in: Obstet Gynecol. 2005 Sep;106(3):644. PMID: 15863547.
33- Clement YN, Onakpoya I, Hung SK, Ernst E. Effects of herbal and dietary supplements on cognition in menopause: a systematic review. Maturitas. 2011 Mar;68(3):256-63. doi: 10.1016/j.maturitas.2010.12.005. Epub 2011 Jan 14. PMID: 21237589.
34- Gafner, Stefan. (2016). Black Cohosh Botanical Adulterants Bulletin.
35- Dennehy C, Tsourounis C. A review of select vitamins and minerals used by postmenopausal women. Maturitas. 2010 Aug;66(4):370-80. doi: 10.1016/j.maturitas.2010.06.003. Epub 2010 Jun 26. PMID: 20580500.
36- Drewe J, Bucher KA, Zahner C. A systematic review of non-hormonal treatments of vasomotor symptoms in climacteric and cancer patients. Springerplus. 2015 Feb 10;4:65. doi: 10.1186/s40064-015-0808-y. PMID: 25713759; PMCID: PMC4331402.
37- Zhu X, Liew Y, Liu ZL. Chinese herbal medicine for menopausal symptoms. Cochrane Database Syst Rev. 2016 Mar 15;3:CD009023. doi: 10.1002/14651858.CD009023.pub2. PMID: 26976671; PMCID: PMC4951187.